One Compartment Model
Single IV Bolus - Simulation

One compartment Model (kel/V)

Parameters

Dose - type 1 parameter, define the component receiving the dose
kel, Elimination Rate Constant - type 2 parameter, define the component receiving the drug (0 means the 'outside' not of interest) and the compenent loosing the drug (not 0).
V, Apparent Volume of Distribution - type 18 parameter, define the data set (by number), a short descriptor for the data set (or line) and the component sampled (enter 0 zero if time).

The file, onec_as.BAT. Copy the lines between the markers '--' but not the marker, starting with 'Boomer Batch File'. Paste into a new text document using a simple text editor such as Text Edit (Macintosh) or Notepad (Windows) and save as plain (ascii) text as onec_as.BAT. Start boomer and enter 1 or 3 to use a .BAT file. Enter the .BAT file name onec_as.

--
Boomer Batch File
    2                             wls,bayes,sim,irwls,sim+error,grid 
    1                             Screen, diskfile                   
onec_as                                                     <- output to onec_as.OUT
    1                             Parameter type            <- start of Dose input
Dose                                                        
   100.0                          Parameter value                    
    1                             To                        <- into component 1
    0                             happy or not                       
    2                             Parameter type            <- start of kel input
kel                                                         
  0.1230                          Parameter value                    
    0                             To                        <- to outside
    1                             From                      <- from component 1
    0                             happy or not                       
   18                             Parameter type            <- start of V input
V                                                           
   12.30                          Parameter value                    
    1                             To                        <- only one data set, 1
[Drug]                                                      
    1                             From                      <- from component 1
    0                             happy or not                       
   -1                             Parameter type            <- end of model definition
    2                             Integration method        <- Fehlberg RKF45 - default
   0.000                          Relative error                     
   0.000                          Absolute error                     
Simulation - Once compartment IV Bolus                      
    1                             Data from disk or keyboard         
   0.000                          X value                            
   0.000                          Y value                            
   1.000                          X value                            
   0.000                          Y value                            
   2.000                          X value                            
   0.000                          Y value                            
   4.000                          X value                            
   0.000                          Y value                            
   6.000                          X value                            
   0.000                          Y value                            
   9.000                          X value                            
   0.000                          Y value                            
   12.00                          X value                            
   0.000                          Y value                            
  -1.000                          X value                     <- end of data entry
    0                             Accept, correct, delete, insert, of
    0                             Continue or save data              
    0                             AUC line number             <- no AUC calculation
    2                             Continue,save,plot,supplemental,sen
   -1                             wls,bayes,sim,irwls,sim+error,grid <- finish
--

When you open onec_as.OUT you should see the information below


 ** FINAL OUTPUT FROM Boomer (v3.3.6) **       4 July 2011 ---  8:31:54 am

 Title:  Simulation - Once compartment IV Bolus                      
 Input: From Keyboard
 Output:  To onec_as.OUT                                                     
 Data for [Drug]          came from keyboard (or ?.BAT)                                             
 Fitting algorithm: Simulation                 
 Numerical integration method: 2) Fehlberg RKF45                          
          with  1 de(s)
 With relative error   0.1000E-03
 With absolute error   0.1000E-03

 This simulation took     0.1000E-01 seconds

 Model and Parameter Definition

  #  Name                    Value       Type From To     Dep  Start Stop

  1) Dose                =   100.0        1    0    1       0    0    0
  2) kel                 =  0.1230        2    1    0       0    0    0
  3) V                   =   12.30       18    1    1       0    0    0

 Data for [Drug]          :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       8.13008       0.00000      -0.00000    
     2    1.000       0.00000       7.18914       0.00000      -0.00000    
     3    2.000       0.00000       6.35709       0.00000      -0.00000    
     4    4.000       0.00000       4.97075       0.00000      -0.00000    
     5    6.000       0.00000       3.88674       0.00000      -0.00000    
     6    9.000       0.00000       2.68738       0.00000      -0.00000    
     7    12.00       0.00000       1.85812       0.00000      -0.00000    
      Plots of observed (*) and calculated values (+)
           versus time for [Drug]         . Superimposed points (X)

    8.130      Linear                      8.130      Semi-log
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 |*  *  *     *     *        *        *  |                                    +
 |_____________________________________  |*__*__*_____*_____*________*________*
    0.000                                  1.858    
 0              <-->             12.     0              <-->             12.

One Compartment Model Single IV Bolus - Simulation

Parameters

One Compartment Model
Single IV Bolus - Simulation