** FINAL OUTPUT FROM Boomer (v3.4.5) **       8 October 2019 --- 10:50:58 am

 Title:  Fit of Data with PBPK Model
 Input: From pbpk_fit.BAT                                                    
 Output:  To pbpk_fit.OUT                                                    
 Data for [Vein] came from keyboard (or ?.BAT)
 Data for [Lung] came from keyboard (or ?.BAT)
 Data for [Artery] came from keyboard (or ?.BAT)
 Data for [Spleen] came from keyboard (or ?.BAT)
 Data for [Liver] came from keyboard (or ?.BAT)
 Data for [Kidney] came from keyboard (or ?.BAT)
 Data for [Heart] came from keyboard (or ?.BAT)
 Data for [Muscle] came from keyboard (or ?.BAT)
 Data for [Other] came from keyboard (or ?.BAT)
 Fitting algorithm: Simplex Method             
 Weighting for [Vein]                                                           by Equal weight                                      
 Weighting for [Lung]                                                           by Equal weight                                      
 Weighting for [Artery]                                                         by Equal weight                                      
 Weighting for [Spleen]                                                         by Equal weight                                      
 Weighting for [Liver]                                                          by Equal weight                                      
 Weighting for [Kidney]                                                         by Equal weight                                      
 Weighting for [Heart]                                                          by Equal weight                                      
 Weighting for [Muscle]                                                         by Equal weight                                      
 Weighting for [Other]                                                          by Equal weight                                      
 Numerical integration method: 4) Gears method with PEDERV                        
          with  9 de(s)
 With absolute error   0.1000E-02
 PC =   0.1000E-04

                    ** FINAL PARAMETER VALUES ***

  #  Name                  Value       S.D.       C.V. %  Lower <-Limit-> Upper

  1) R Lung > Artery       0.90806                           0.50       2.0    
  2) R Spleen > Liver      0.91330                           0.50       2.0    
  3) R Liver > Vein        0.91488                           0.50       2.0    
  4) R Kidney > Vein       0.90266                           0.50       2.0    
  5) R Heart > Vein        0.87088                           0.50       2.0    
  6) R Muscle > Vein       0.99699                           0.50       2.0    
  7) R Other > Vein         1.0421                           0.50       2.0    
  8) Elimination            1.4850                            0.0       10.    

 Final WSS =   0.152115E-05  R^2 =   0.9929     Corr. Coeff =   0.9964    
 AIC =   -653.802            AICc =   -650.802    
 Log likelihood =   362.     Schwarz Criteria =   -638.506    
 R^2 and R - jp1     0.9929        0.9964    
 R^2 and R - jp2     0.9928        0.9964    
 RMSE =     0.1744E-03 or         10.294 % RMSE
 MAE  =     0.1268E-03 ME =     0.1020E-04

 ** FINAL OUTPUT FROM Boomer (v3.4.5) **       8 October 2019 --- 10:50:58 am

 Title:  Fit of Data with PBPK Model
 Input: From pbpk_fit.BAT                                                    
 Output:  To pbpk_fit.OUT                                                    
 Data for [Vein] came from keyboard (or ?.BAT)
 Data for [Lung] came from keyboard (or ?.BAT)
 Data for [Artery] came from keyboard (or ?.BAT)
 Data for [Spleen] came from keyboard (or ?.BAT)
 Data for [Liver] came from keyboard (or ?.BAT)
 Data for [Kidney] came from keyboard (or ?.BAT)
 Data for [Heart] came from keyboard (or ?.BAT)
 Data for [Muscle] came from keyboard (or ?.BAT)
 Data for [Other] came from keyboard (or ?.BAT)
 Fitting algorithm: DAMPING-GAUSS/SIMPLEX      
 Weighting for [Vein]                                                           by Equal weight                                      
 Weighting for [Lung]                                                           by Equal weight                                      
 Weighting for [Artery]                                                         by Equal weight                                      
 Weighting for [Spleen]                                                         by Equal weight                                      
 Weighting for [Liver]                                                          by Equal weight                                      
 Weighting for [Kidney]                                                         by Equal weight                                      
 Weighting for [Heart]                                                          by Equal weight                                      
 Weighting for [Muscle]                                                         by Equal weight                                      
 Weighting for [Other]                                                          by Equal weight                                      
 Numerical integration method: 4) Gears method with PEDERV                        
          with  9 de(s)
 With absolute error   0.1000E-02
 DT =   0.1000E-02     PC =   0.1000E-04 Loops =     1
 Damping =    21

                    ** FINAL PARAMETER VALUES ***

  #  Name                  Value       S.D.       C.V. %  Lower <-Limit-> Upper

  1) R Lung > Artery       0.90806      0.397E-01   4.4      0.50       2.0    
  2) R Spleen > Liver      0.91330      0.163E-01   1.8      0.50       2.0    
  3) R Liver > Vein        0.91488      0.229E-01   2.5      0.50       2.0    
  4) R Kidney > Vein       0.90266      0.158E-01   1.8      0.50       2.0    
  5) R Heart > Vein        0.87088      0.253E-01   2.9      0.50       2.0    
  6) R Muscle > Vein       0.99699      0.203       20.      0.50       2.0    
  7) R Other > Vein         1.0421      0.425E-01   4.1      0.50       2.0    
  8) Elimination            1.4850      0.362E-01   2.4       0.0       10.    

 Final WSS =   0.152115E-05  R^2 =   0.9929     Corr. Coeff =   0.9964    
 AIC =   -653.802            AICc =   -650.802    
 Log likelihood =   362.     Schwarz Criteria =   -638.506    
 R^2 and R - jp1     0.9929        0.9964    
 R^2 and R - jp2     0.9928        0.9964    
 RMSE =     0.1744E-03 or         10.294 % RMSE
 MAE  =     0.1268E-03 ME =     0.1020E-04

 Model and Parameter Definition

  #  Name                    Value       Type From To     Dep  Start Stop

  1) Dose                =   100.0        1    0    1       0    0    0
  2) Q Vein > Lung       =   2700.       15    1    3       0    0    0
  3) V Vein > Lung       =   800.0       16    1    1       0    0    0
  4) R Vein > Lung       =   1.000       17    0    0       0    0    0
  5) Q Lung > Artery     =   2700.       15    3    2       0    0    0
  6) V Lung > Artery     =   375.0       16    3    2       0    0    0
  7) R Lung > Artery     =  0.9081       17    0    0       0    0    0
  8) Q Artery > Liver    =   460.0       15    2    4       0    0    0
  9) V Artery > Liver    =   1600.       16    2    3       0    0    0
 10) R Artery > Liver    =   1.000       17    0    0       0    0    0
 11) Q Artery > Spleen   =   75.00       15    2    5       0    0    0
 12) V Artery > Spleen   =   1600.       16    2    0   10900    0    0
 13) R Artery > Spleen   =   1.000       17    0    0   11000    0    0
 14) Q Spleen > Liver    =   75.00       15    5    4       0    0    0
 15) V Spleen > Liver    =   60.00       16    5    4       0    0    0
 16) R Spleen > Liver    =  0.9133       17    0    0       0    0    0
 17) Q Artery > Kidney   =   330.0       15    2    6       0    0    0
 18) V Artery > Kidney   =   1600.       16    2    0   10900    0    0
 19) R Artery > Kidney   =   1.000       17    0    0   11000    0    0
 20) Q Artery > Heart    =   97.00       15    2    7       0    0    0
 21) V Artery > Heart    =   1600.       16    2    0   10900    0    0
 22) R Artery > Heart    =   1.000       17    0    0   11000    0    0
 23) Q Artery > Muscle   =   280.0       15    2    8       0    0    0
 24) V Artery > Muscle   =   1600.       16    2    0   10900    0    0
 25) R Artery > Muscle   =   1.000       17    0    0   11000    0    0
 26) Q Artery > Other    =   1458.       15    2    9       0    0    0
 27) V Artery > Other    =   1600.       16    2    0   10900    0    0
 28) R Artery > Other    =   1.000       17    0    0   11000    0    0
 29) Q Liver > Vein      =   535.0       15    4    1       0    0    0
 30) V Liver > Vein      =   790.0       16    4    5       0    0    0
 31) R Liver > Vein      =  0.9149       17    0    0       0    0    0
 32) Q Kidney > Vein     =   330.0       15    6    1       0    0    0
 33) V Kidney > Vein     =   165.0       16    6    6       0    0    0
 34) R Kidney > Vein     =  0.9027       17    0    0       0    0    0
 35) Q Heart > Vein      =   97.00       15    7    1       0    0    0
 36) V Heart > Vein      =   200.0       16    7    7       0    0    0
 37) R Heart > Vein      =  0.8709       17    0    0       0    0    0
 38) Q Muscle > Vein     =   280.0       15    8    1       0    0    0
 39) V Muscle > Vein     =  0.1830E+05   16    8    8       0    0    0
 40) R Muscle > Vein     =  0.9970       17    0    0       0    0    0
 41) Q Other > Vein      =   1458.       15    9    1       0    0    0
 42) V Other > Vein      =  0.1171E+05   16    9    9       0    0    0
 43) R Other > Vein      =   1.042       17    0    0       0    0    0
 44) Elimination         =   1.485        2    1    0       0    0    0

 Flow balance for Physiological Model

 Component  1) in    2700.     out    2700.    
 Component  2) in    2700.     out    2700.    
 Component  3) in    2700.     out    2700.    
 Component  4) in    535.0     out    535.0    
 Component  5) in    75.00     out    75.00    
 Component  6) in    330.0     out    330.0    
 Component  7) in    97.00     out    97.00    
 Component  8) in    280.0     out    280.0    
 Component  9) in    1458.     out    1458.    


 Data for [Vein] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000      0.125000       0.00000      -0.00000    
     2    1.000      0.400000E-02  0.393506E-02   1.00000      0.649435E-04
     3    2.000      0.300000E-02  0.338609E-02   1.00000     -0.386092E-03
     4    4.000      0.200000E-02  0.228926E-02   1.00000     -0.289258E-03
     5    6.000      0.200000E-02  0.177723E-02   1.00000      0.222766E-03
     6    12.00      0.100000E-02  0.118692E-02   1.00000     -0.186920E-03
     7    18.00      0.900000E-03  0.888192E-03   1.00000      0.118081E-04
     8    24.00      0.700000E-03  0.678239E-03   1.00000      0.217608E-04

 WSS data set  1 =   0.3221E-06 R^2 =   0.9705     Corr. Coeff. =   0.9852    
 R^2 and R - jp1     0.9705        0.9852    
 R^2 and R - jp2     0.9637        0.9817    
 RMSE =     0.2145E-03 or         11.099 % RMSE
 MAE  =     0.1691E-03 ME =     0.7728E-04

 Data for [Lung] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    2.000      0.300000E-02  0.314107E-02   1.00000     -0.141067E-03
     3    4.000      0.200000E-02  0.212254E-02   1.00000     -0.122544E-03
     4    6.000      0.200000E-02  0.163501E-02   1.00000      0.364991E-03
     5    12.00      0.100000E-02  0.108491E-02   1.00000     -0.849084E-04
     6    18.00      0.800000E-03  0.811265E-03   1.00000     -0.112653E-04
     7    24.00      0.600000E-03  0.619298E-03   1.00000     -0.192975E-04

 WSS data set  2 =   0.1758E-06 R^2 =   0.9609     Corr. Coeff. =   0.9803    
 R^2 and R - jp1     0.9609        0.9803    
 R^2 and R - jp2     0.9589        0.9792    
 RMSE =     0.2315E-03 or         11.921 % RMSE
 MAE  =     0.1936E-03 ME =     0.9379E-04

 Data for [Artery] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    2.000      0.600000E-02  0.584705E-02   1.00000      0.152950E-03
     3    4.000      0.300000E-02  0.269434E-02   1.00000      0.305656E-03
     4    6.000      0.200000E-02  0.194123E-02   1.00000      0.587672E-04
     5    12.00      0.100000E-02  0.123401E-02   1.00000     -0.234013E-03
     6    18.00      0.900000E-03  0.918777E-03   1.00000     -0.187769E-04
     7    24.00      0.700000E-03  0.700260E-03   1.00000     -0.259955E-06

 WSS data set  3 =   0.1754E-06 R^2 =   0.9943     Corr. Coeff. =   0.9972    
 R^2 and R - jp1     0.9943        0.9972    
 R^2 and R - jp2     0.9914        0.9957    
 RMSE =     0.2315E-03 or         11.921 % RMSE
 MAE  =     0.1936E-03 ME =     0.9379E-04

 Data for [Spleen] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    2.000      0.900000E-02  0.889138E-02   1.00000      0.108622E-03
     3    4.000      0.300000E-02  0.334257E-02   1.00000     -0.342569E-03
     4    6.000      0.200000E-02  0.202339E-02   1.00000     -0.233916E-04
     5    12.00      0.100000E-02  0.117570E-02   1.00000     -0.175699E-03
     6    18.00      0.900000E-03  0.868980E-03   1.00000      0.310199E-04
     7    24.00      0.700000E-03  0.660938E-03   1.00000      0.390621E-04

 WSS data set  4 =   0.1631E-06 R^2 =   0.9974     Corr. Coeff. =   0.9987    
 R^2 and R - jp1     0.9974        0.9987    
 R^2 and R - jp2     0.9968        0.9984    
 RMSE =     0.2315E-03 or         11.921 % RMSE
 MAE  =     0.1936E-03 ME =     0.9379E-04

 Data for [Liver] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    2.000      0.800000E-02  0.818439E-02   1.00000     -0.184388E-03
     3    6.000      0.300000E-02  0.260231E-02   1.00000      0.397695E-03
     4    12.00      0.100000E-02  0.124628E-02   1.00000     -0.246279E-03
     5    18.00      0.900000E-03  0.903145E-03   1.00000     -0.314548E-05
     6    24.00      0.700000E-03  0.684945E-03   1.00000      0.150554E-04

 WSS data set  5 =   0.2531E-06 R^2 =   0.9937     Corr. Coeff. =   0.9969    
 R^2 and R - jp1     0.9937        0.9969    
 R^2 and R - jp2     0.9934        0.9967    
 RMSE =     0.2536E-03 or         13.045 % RMSE
 MAE  =     0.2300E-03 ME =     0.1149E-03

 Data for [Kidney] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    2.000      0.800000E-02  0.800700E-02   1.00000     -0.699703E-05
     3    6.000      0.200000E-02  0.187185E-02   1.00000      0.128155E-03
     4    12.00      0.100000E-02  0.114236E-02   1.00000     -0.142364E-03
     5    18.00      0.900000E-03  0.847258E-03   1.00000      0.527420E-04
     6    24.00      0.700000E-03  0.644958E-03   1.00000      0.550420E-04

 WSS data set  6 =   0.4255E-07 R^2 =   0.9989     Corr. Coeff. =   0.9995    
 R^2 and R - jp1     0.9989        0.9995    
 R^2 and R - jp2     0.9989        0.9994    
 RMSE =     0.2536E-03 or         13.045 % RMSE
 MAE  =     0.2300E-03 ME =     0.1149E-03

 Data for [Heart] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    2.000      0.700000E-02  0.708912E-02   1.00000     -0.891243E-04
     3    6.000      0.300000E-02  0.272503E-02   1.00000      0.274971E-03
     4    12.00      0.100000E-02  0.124141E-02   1.00000     -0.241413E-03
     5    18.00      0.900000E-03  0.877487E-03   1.00000      0.225127E-04
     6    24.00      0.700000E-03  0.663244E-03   1.00000      0.367559E-04

 WSS data set  7 =   0.1437E-06 R^2 =   0.9950     Corr. Coeff. =   0.9975    
 R^2 and R - jp1     0.9950        0.9975    
 R^2 and R - jp2     0.9950        0.9975    
 RMSE =     0.2536E-03 or         13.045 % RMSE
 MAE  =     0.2300E-03 ME =     0.1149E-03

 Data for [Muscle] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    2.000      0.400000E-03  0.397405E-03   1.00000      0.259519E-05
     3    6.000      0.550000E-03  0.552090E-03   1.00000     -0.208971E-05
     4    12.00      0.630000E-03  0.635704E-03   1.00000     -0.570418E-05
     5    18.00      0.660000E-03  0.672992E-03   1.00000     -0.129925E-04
     6    24.00      0.670000E-03  0.684121E-03   1.00000     -0.141206E-04

 WSS data set  8 =   0.4118E-09 R^2 =   0.9994     Corr. Coeff. =   0.9997    
 R^2 and R - jp1     0.9994        0.9997    
 R^2 and R - jp2     0.9918        0.9959    
 RMSE =     0.2536E-03 or         13.045 % RMSE
 MAE  =     0.2300E-03 ME =     0.1149E-03

 Data for [Other] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    2.000      0.300000E-02  0.287934E-02   1.00000      0.120658E-03
     3    6.000      0.300000E-02  0.293241E-02   1.00000      0.675884E-04
     4    12.00      0.200000E-02  0.221751E-02   1.00000     -0.217505E-03
     5    18.00      0.200000E-02  0.164099E-02   1.00000      0.359008E-03
     6    24.00      0.100000E-02  0.122294E-02   1.00000     -0.222945E-03

 WSS data set  9 =   0.2450E-06 R^2 =   0.9167     Corr. Coeff. =   0.9575    
 R^2 and R - jp1     0.9167        0.9575    
 R^2 and R - jp2     0.9125        0.9552    
 RMSE =     0.2536E-03 or         13.045 % RMSE
 MAE  =     0.2300E-03 ME =     0.1149E-03
      Plots of observed (*) and calculated values (+)
           versus time for [Vein]. Superimposed points (X)

   0.1250      Linear                     0.1250      Semi-log
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 |*X X  X  X        X        X        X  |                                    X
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    0.000                                 0.6782E-03
 0              <-->             24.     0              <-->             24.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for [Vein]                versus log(calc Cp(i)) for [Vein]         

    1.290                                  1.290    
 |         X                             |      X                              
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 0X==========================X========X  0XX==================================X
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   -2.236                                 -2.236    
      0.0       <-->             24.         0.68E-03   <-->            0.12    
      Plots of observed (*) and calculated values (+)
           versus time for [Lung]. Superimposed points (X)

   0.3141E-02  Linear                     0.3141E-02  Semi-log
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    0.000                                 0.6000E-03
 0              <-->             24.     0              <-->             24.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for [Lung]                versus log(calc Cp(i)) for [Lung]         

    2.113                                  2.113    
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 0X==========================X=========  0=====X===============================
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  -0.8168                                -0.8168    
      0.0       <-->             24.         0.62E-03   <-->            0.31E-02
      Plots of observed (*) and calculated values (+)
           versus time for [Artery]. Superimposed points (X)

   0.6000E-02  Linear                     0.6000E-02  Semi-log
 |   *                                   |   *                                 
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 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |      *                              
 |                                       |                                     
 |                                       |      +                              
 |                                       |                                     
 |                                       |                                     
 |      *                                |                                     
 |                                       |         X                           
 |      +                                |                                     
 |                                       |                                     
 |                                       |                                     
 |         *                             |                                     
 |         +                             |                                     
 |                                       |                                     
 |                                       |                  +                  
 |                  +                    |                                     
 |                  *                    |                                     
 |                           X           |                  *                  
 |                                    X  |                           X         
 |                                       |                                     
 |                                       |                                     
 |X                                      |                                    X
 |_____________________________________  |X____________________________________
    0.000                                 0.7000E-03
 0              <-->             24.     0              <-->             24.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for [Artery]              versus log(calc Cp(i)) for [Artery]       

    1.770                                  1.770    
 |      X                                |                      X              
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |   X                                   |                                   X 
 |                                       |                                     
 |                                       |                                     
 |         X                             |                 X                   
 |                                       |                                     
 0X==========================X========X  0X===X================================
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                  X                    |         X                           
 |                                       |                                     
   -1.355                                 -1.355    
      0.0       <-->             24.         0.70E-03   <-->            0.58E-02
      Plots of observed (*) and calculated values (+)
           versus time for [Spleen]. Superimposed points (X)

   0.9000E-02  Linear                     0.9000E-02  Semi-log
 |   *                                   |   *                                 
 |   +                                   |   +                                 
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |      +                              
 |                                       |      *                              
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |         X                           
 |      +                                |                                     
 |      *                                |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |         X                             |                  +                  
 |                                       |                                     
 |                                       |                  *                  
 |                  X        *           |                           X         
 |                           +        X  |                                     
 |                                       |                                     
 |X                                      |                                    X
 |_____________________________________  |X____________________________________
    0.000                                 0.6609E-03
 0              <-->             24.     0              <-->             24.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for [Spleen]              versus log(calc Cp(i)) for [Spleen]       

   0.6290                                 0.6290    
 |   X                                   |                                    X
 |                                       |                                     
 |                                       |                                     
 |                           X        X  |X  X                                 
 0X====================================  0=====================================
 |         X                             |               X                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                  X                    |       X                             
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |      X                                |                      X              
 |                                       |                                     
   -1.984                                 -1.984    
      0.0       <-->             24.         0.66E-03   <-->            0.89E-02
      Plots of observed (*) and calculated values (+)
           versus time for [Liver]. Superimposed points (X)

   0.8184E-02  Linear                     0.8184E-02  Semi-log
 |   +                                   |   +                                 
 |   *                                   |   *                                 
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |         *                           
 |                                       |         +                           
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |         *                             |                                     
 |         +                             |                                     
 |                                       |                                     
 |                                       |                  +                  
 |                                       |                                     
 |                                       |                                     
 |                  +                    |                  *                  
 |                  *        X           |                           X         
 |                                    X  |                                     
 |                                       |                                     
 |X                                      |                                    X
 |_____________________________________  |X____________________________________
    0.000                                 0.6849E-03
 0              <-->             24.     0              <-->             24.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for [Liver]               versus log(calc Cp(i)) for [Liver]        

    2.303                                  2.303    
 |         X                             |                   X                 
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 0X==========================X========X  0X===X================================
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |   X                                   |                                    X
 |                  X                    |        X                            
 |                                       |                                     
   -1.426                                 -1.426    
      0.0       <-->             24.         0.68E-03   <-->            0.82E-02
      Plots of observed (*) and calculated values (+)
           versus time for [Kidney]. Superimposed points (X)

   0.8007E-02  Linear                     0.8007E-02  Semi-log
 |   +                                   |   +                                 
 |   *                                   |   *                                 
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |         *                           
 |                                       |         +                           
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |         X                             |                                     
 |                                       |                  +                  
 |                                       |                  *                  
 |                  +                    |                                     
 |                  *        X           |                           X         
 |                                    X  |                                     
 |                                       |                                     
 |X                                      |                                    X
 |_____________________________________  |X____________________________________
    0.000                                 0.6450E-03
 0              <-->             24.     0              <-->             24.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for [Kidney]              versus log(calc Cp(i)) for [Kidney]       

   0.7421                                 0.7421    
 |                                       |                                     
 |         X                             |               X                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                           X        X  |X  X                                 
 |                                       |                                     
 |                                       |                                     
 0X==X=================================  0====================================X
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                  X                    |        X                            
 |                                       |                                     
  -0.8243                                -0.8243    
      0.0       <-->             24.         0.64E-03   <-->            0.80E-02
      Plots of observed (*) and calculated values (+)
           versus time for [Heart]. Superimposed points (X)

   0.7089E-02  Linear                     0.7089E-02  Semi-log
 |   +                                   |   +                                 
 |   *                                   |   *                                 
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |         *                           
 |                                       |                                     
 |                                       |         +                           
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |         *                             |                                     
 |         +                             |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                  +                  
 |                                       |                                     
 |                  +                    |                  *                  
 |                  *                    |                                     
 |                           X           |                           X         
 |                                    X  |                                     
 |                                       |                                     
 |X                                      |                                    X
 |_____________________________________  |X____________________________________
    0.000                                 0.6632E-03
 0              <-->             24.     0              <-->             24.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for [Heart]               versus log(calc Cp(i)) for [Heart]        

    1.592                                  1.592    
 |         X                             |                     X               
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                           X        X  |X   X                                
 0X====================================  0=====================================
 |                                       |                                     
 |                                       |                                     
 |   X                                   |                                    X
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                  X                    |         X                           
 |                                       |                                     
   -1.398                                 -1.398    
      0.0       <-->             24.         0.66E-03   <-->            0.71E-02
      Plots of observed (*) and calculated values (+)
           versus time for [Muscle]. Superimposed points (X)

   0.6841E-03  Linear                     0.6841E-03  Semi-log
 |                                    +  |                                    +
 |                           +        *  |                  +        X        *
 |                           *           |                  *                  
 |                  X                    |         X                           
 |                                       |                                     
 |                                       |                                     
 |         X                             |                                     
 |                                       |   *                                 
 |                                       |   +                                 
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |   X                                   |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |X                                      |                                     
 |_____________________________________  |X____________________________________
    0.000                                 0.6841E-04
 0              <-->             24.     0              <-->             24.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for [Muscle]              versus log(calc Cp(i)) for [Muscle]       

   0.1503E-01                             0.1503E-01
 |   X                                   |X                                    
 |                                       |                                     
 |                                       |                                     
 0X====================================  0=====================================
 |                                       |                                     
 |         X                             |                     X               
 |                                       |                                     
 |                                       |                                     
 |                  X                    |                               X     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                           X           |                                  X  
 |                                    X  |                                    X
 |                                       |                                     
  -0.8176E-01                            -0.8176E-01
      0.0       <-->             24.         0.40E-03   <-->            0.68E-03
      Plots of observed (*) and calculated values (+)
           versus time for [Other]. Superimposed points (X)

   0.3000E-02  Linear                     0.3000E-02  Semi-log
 |   *     *                             |   *     *                           
 |         +                             |         +                           
 |   +                                   |   +                                 
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                  +                    |                                     
 |                                       |                  +                  
 |                  *        *           |                                     
 |                                       |                                     
 |                                       |                  *        *         
 |                                       |                                     
 |                           +           |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                           +         
 |                                    +  |                                     
 |                                       |                                     
 |                                    *  |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                    +
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |X                                      |                                    *
 |_____________________________________  |X____________________________________
    0.000                                 0.1000E-02
 0              <-->             24.     0              <-->             24.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for [Other]               versus log(calc Cp(i)) for [Other]        

    2.079                                  2.079    
 |                           X           |            X                        
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |   X                                   |                                   X 
 |                                       |                                     
 |         X                             |                                    X
 0X====================================  0=====================================
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                  X                 X  |X                       X            
 |                                       |                                     
   -1.291                                 -1.291    
      0.0       <-->             24.         0.12E-02   <-->            0.29E-02
 Plot of Std Wtd Residuals (X)        Plot of Std Wtd  Residuals (X)
   versus time for all data              versus log(calc Cp(i)) for all data       

    2.303                                  2.303    
 |         X                             |           X                         
 |         X                 X           |        X                            
 |      X                                |           X                         
 |         X                             |            X                        
 |         X                             |         X                           
 |   X                                   |                X                    
 |   X     X                             |         X  X      X                 
 | X       X                          X  |   X     X  X X                      
 |                           X        X  |   XXX                               
 0X==X=====X========X========X========X  0X=XXXX====X=======X=================X
 |   X              X                    |      X           X                  
 |   X  X                                |          X X                        
 |   X              X                    |      X           X                  
 |                  X                 X  |       X  X                          
 |                  X                    |       X                             
 |      X                                |          X                          
 |   X  X                                |             X                       
 |                                       |                                     
   -2.236                                 -2.236    
      0.0       <-->             24.         0.40E-03   <-->            0.12