** FINAL OUTPUT FROM Boomer (v3.4.5) **       5 March 2020 ---  1:06:06 pm

 Title:  Fit to PK PD Model
 Input: From fit.BAT                                                         
 Output:  To fit.OUT                                                         
 Data for Cp came from keyboard (or ?.BAT)
 Data for Response came from keyboard (or ?.BAT)
 Fitting algorithm: Simplex Method             
 Weighting for Cp                                                               by 1/Cp(Obs )^2                                      
 Weighting for Response                                                         by 1/Cp(Obs )^2                                      
 Numerical integration method: 2) Fehlberg RKF45                                  
          with  3 de(s)
 With relative error   0.1000E-03
 With absolute error   0.1000E-03
 PC =   0.1000E-04

                    ** FINAL PARAMETER VALUES ***

  #  Name                  Value       S.D.       C.V. %  Lower <-Limit-> Upper

  1) k10                   0.19955                           0.10      0.40    
  2) k12                    1.2669                           0.60       2.6    
  3) k21                    1.0731                           0.50       2.2    
  4) V1                     12.079                            6.0       24.    
  5) ke0                   0.82420                           0.20       3.2    
  6) Ec(50%) or b Emax     0.24885                           0.10      0.50    
  7) S or i Emax            1.4997                           0.70       3.0    

 Final WSS =   0.917330E-02  R^2 =   0.9998     Corr. Coeff =   0.9999    
 AIC =   -122.052            AICc =   -117.052    
 Log likelihood =   75.7     Schwarz Criteria =   -112.481    
 R^2 and R - jp1     0.9996        0.9998    
 R^2 and R - jp2     0.9996        0.9998    
 RMSE =     0.4701     or          1.779 % RMSE
 MAE  =     0.2692     ME =    -0.6507E-01

 ** FINAL OUTPUT FROM Boomer (v3.4.5) **       5 March 2020 ---  1:06:06 pm

 Title:  Fit to PK PD Model
 Input: From fit.BAT                                                         
 Output:  To fit.OUT                                                         
 Data for Cp came from keyboard (or ?.BAT)
 Data for Response came from keyboard (or ?.BAT)
 Fitting algorithm: DAMPING-GAUSS/SIMPLEX      
 Weighting for Cp                                                               by 1/Cp(Obs )^2                                      
 Weighting for Response                                                         by 1/Cp(Obs )^2                                      
 Numerical integration method: 2) Fehlberg RKF45                                  
          with  3 de(s)
 With relative error   0.1000E-03
 With absolute error   0.1000E-03
 DT =   0.1000E-02     PC =   0.1000E-04 Loops =     3
 Damping =     4

                    ** FINAL PARAMETER VALUES ***

  #  Name                  Value       S.D.       C.V. %  Lower <-Limit-> Upper

  1) k10                   0.19707      0.305E-02   1.5      0.10      0.40    
  2) k12                    1.1945      0.737E-01   6.2      0.60       2.6    
  3) k21                    1.0382      0.479E-01   4.6      0.50       2.2    
  4) V1                     12.225      0.178       1.5       6.0       24.    
  5) ke0                   0.82833      0.151E-01   1.8      0.20       3.2    
  6) Ec(50%) or b Emax     0.25075      0.333E-02   1.3      0.10      0.50    
  7) S or i Emax            1.4951      0.103E-01  0.69      0.70       3.0    

 Final WSS =   0.871169E-02  R^2 =   0.9997     Corr. Coeff =   0.9999    
 AIC =   -123.550            AICc =   -118.550    
 Log likelihood =   76.5     Schwarz Criteria =   -113.979    
 R^2 and R - jp1     0.9996        0.9998    
 R^2 and R - jp2     0.9996        0.9998    
 RMSE =     0.4835     or          1.733 % RMSE
 MAE  =     0.2775     ME =    -0.7631E-01

 Model and Parameter Definition

  #  Name                    Value       Type From To     Dep  Start Stop

  1) Dose                =   200.0        1    0    1       0    0    0
  2) k10                 =  0.1971        2    1    0       0    0    0
  3) k12                 =   1.194        2    1    2       0    0    0
  4) k21                 =   1.038        2    2    1       0    0    0
  5) V1                  =   12.23       18    1    1       0    0    0
  6) k1e                 =  0.1000E-01    2    1    3       0    0    0
  7) -k1e                = -0.1000E-01    2    1    0       0    0    0
  8) ke0                 =  0.8283        2    3    0       0    0    0
  9) Emax or a Emax      =   100.0       11    3    2       0    0    0
 10) Ec(50%) or b Emax   =  0.2507       12    0    0       0    0    0
 11) S or i Emax         =   1.495       13    0    0       0    0    0

 Data for Cp :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       16.3599       0.00000      -0.00000    
     2   0.5000E-01   15.0000       15.2841      0.666667E-01 -0.189425E-01
     3   0.1000       14.0000       14.3241      0.714286E-01 -0.231484E-01
     4   0.1500       14.0000       13.4669      0.714286E-01  0.380753E-01
     5   0.2000       13.0000       12.7014      0.769231E-01  0.229708E-01
     6   0.2500       12.0000       12.0173      0.833333E-01 -0.143957E-02
     7   0.5000       9.40000       9.53657      0.106383     -0.145292E-01
     8    1.000       7.20000       7.23043      0.138889     -0.422683E-02
     9    2.000       5.90000       5.87982      0.169492      0.342022E-02
    10    4.000       4.90000       4.86490      0.204082      0.716287E-02
    11    9.000       3.20000       3.14295      0.312500      0.178287E-01
    12    12.00       2.40000       2.41845      0.416667     -0.768781E-02
    13    18.00       1.40000       1.43198      0.714286     -0.228405E-01
    14    24.00      0.850000      0.847885       1.17647      0.248811E-02
    15    30.00      0.500000      0.502038       2.00000     -0.407684E-02
    16    36.00      0.300000      0.297256       3.33333      0.914802E-02

 WSS data set  1 =   0.4171E-02 R^2 =   0.9986     Corr. Coeff. =   0.9993    
 R^2 and R - jp1     0.9996        0.9998    
 R^2 and R - jp2     0.9996        0.9998    
 RMSE =     0.1975     or          1.668 % RMSE
 MAE  =     0.1196     ME =    -0.6927E-02

 Data for Response :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2   0.1000E-01   2.20000       2.19383      0.454545      0.280424E-02
     3   0.2000E-01   5.80000       5.85533      0.172414     -0.953921E-02
     4   0.5000E-01   19.0000       18.8989      0.526316E-01  0.531980E-02
     5   0.1000       38.0000       37.7362      0.263158E-01  0.694275E-02
     6   0.2000       59.0000       59.3721      0.169492E-01 -0.630757E-02
     7   0.5000       79.0000       78.8822      0.126582E-01  0.149073E-02
     8    1.000       85.0000       85.1443      0.117647E-01 -0.169785E-02
     9    2.000       87.0000       86.6743      0.114943E-01  0.374323E-02
    10    6.000       82.0000       81.3412      0.121951E-01  0.803403E-02
    11    12.00       68.0000       66.6963      0.147059E-01  0.191723E-01
    12    18.00       49.0000       47.7762      0.204082E-01  0.249752E-01
    13    24.00       28.0000       29.4720      0.357143E-01 -0.525708E-01
    14    30.00       16.0000       16.0282      0.625000E-01 -0.176525E-02
    15    36.00       8.20000       8.01970      0.121951      0.219884E-01

 WSS data set  2 =   0.4540E-02 R^2 =   0.9996     Corr. Coeff. =   0.9998    
 R^2 and R - jp1     0.9995        0.9998    
 R^2 and R - jp2     0.9995        0.9998    
 RMSE =     0.2045     or          1.709 % RMSE
 MAE  =     0.1279     ME =    -0.7225E-02
      Plots of observed (*) and calculated values (+)
           versus time for Cp. Superimposed points (X)

    16.36      Linear                      16.36      Semi-log
 |+                                      |+                                    
 |                                       |+                                    
 |+                                      |X                                    
 |*                                      |X                                    
 |+                                      |                                     
 |*                                      |X                                    
 |+                                      |                                     
 |X                                      | X                                   
 |X                                      |  X                                  
 |                                       |                                     
 |                                       |    X                                
 |                                       |                                     
 |                                       |                                     
 |X                                      |         X                           
 |                                       |                                     
 |                                       |            X                        
 |                                       |                                     
 | X                                     |                                     
 |                                       |                                     
 |                                       |                  X                  
 |  X                                    |                                     
 |                                       |                                     
 |    X                                  |                                     
 |                                       |                        X            
 |                                       |                                     
 |         X                             |                                     
 |            X                          |                                     
 |                                       |                              X      
 |                  X                    |                                     
 |                        X              |                                     
 |*                             X     X  |                                    X
 |_____________________________________  |*____________________________________
    0.000                                 0.2973    
 0              <-->             36.     0              <-->             36.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for Cp                    versus log(calc Cp(i)) for Cp             

    1.998                                  1.998    
 |X                                      |                                  X  
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |X                                      |                                 X   
 |                                       |                                     
 |         X                             |                     X               
 |                                       |                                     
 |                                    X  |X                                    
 |    X                                  |                         X           
 0X=X=====================X============  0=========X================X=========X
 |X                                      |                                 X   
 | X          X                 X        |    X             X         X        
 |                                       |                                     
 |X                                      |                               X     
 |X                                      |                                   X 
 |X                 X                    |              X                   X  
 |                                       |                                     
   -1.215                                 -1.215    
      0.0       <-->             36.         0.30       <-->             16.    
      Plots of observed (*) and calculated values (+)
           versus time for Response. Superimposed points (X)

    87.00      Linear                      87.00      Semi-log
 |  *                                    |  *                                  
 | X+                                    |XX+   X                              
 |      X                                |                                     
 |X                                      |            X                        
 |                                       |X                                    
 |                                       |                  X                  
 |                                       |                                     
 |            *                          |X                                    
 |            +                          |                                     
 |                                       |                        +            
 |X                                      |                        *            
 |                                       |                                     
 |                                       |                                     
 |                                       |X                                    
 |                  X                    |                              X      
 |                                       |                                     
 |                                       |                                     
 |X                                      |                                     
 |                                       |                                     
 |                                       |                                     
 |                        +              |                                    X
 |                        *              |                                     
 |                                       |+                                    
 |                                       |*                                    
 |X                                      |                                     
 |                              X        |                                     
 |                                       |                                     
 |                                       |                                     
 |X                                   X  |                                     
 |                                       |                                     
 |X                                      |X                                    
 |_____________________________________  |X____________________________________
    0.000                                  2.194    
 0              <-->             36.     0              <-->             36.    
 Plot of Std Wtd Residuals (X)         Plot of Std Wtd  Residuals (X)
   versus time for Response              versus log(calc Cp(i)) for Response       

    1.311                                  1.311    
 |                  X                    |                              X      
 |                                    X  |            X                        
 |            X                          |                                 X   
 |                                       |                                     
 |X     X                                |                           X       X 
 |X X                                    |X                    X             XX
 0XX============================X======  0===================X===============X=
 |X                                      |                                X    
 |X                                      |         X                           
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                        X              |                         X           
 |                                       |                                     
   -2.759                                 -2.759    
      0.0       <-->             36.          2.2       <-->             87.    
 Plot of Std Wtd Residuals (X)        Plot of Std Wtd  Residuals (X)
   versus time for all data              versus log(calc Cp(i)) for all data       

    1.998                                  1.998    
 |X                                      |                        X            
 |                                       |                                     
 |                                       |                                     
 |X                 X                 X  |                    X  X        X    
 |         X  X                          |              X                   X  
 |                                       |                                     
 |X   X X                             X  |X                X        X   X    X 
 0X=X=====================X============  0======X=====X=====X====X=X=========XX
 |XX                            X        |   X                X    X       X X 
 |X           X                          |             X    X                  
 |X                                      |                      X              
 |X                 X                    |         X              X            
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                        X              |                             X       
 |                                       |                                     
   -2.759                                 -2.759    
      0.0       <-->             36.         0.30       <-->             87.