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Fig 3.18.1 Slide showing plasma concentration time curves for three theoretical formulations with different ka values. The plasma concentrations achieved can be controlled by the rate of drug absorption. As shown product I would be toxic. A smaller dose, or a slower formulation should be considered. Formulation II appears to be effective in the dose and formulation used. The dosage form III appears to be too slow and thereby ineffective. If it is a drug requiring a sustained effect this formulation may be more useful at a higher dose or after repeated doses.
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