Chapter 3

Biopharmaceutics and Pharmacokinetic Introduction

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Renal Disease and Drug Elimination

Fig 3.24.1 Slide showing relationship between kanamycin half-life and serum creatinine level. As kidney function is reduced the serum creatinine level increases and the also the kanamycin takes longer to be eliminated from the body.

• Cutler, R.E. and Orme, B.M. 1969 Correlation of Serum Creatinine Concentration and Kanamycin Half-Life, J. Amer. Med. Assoc., 209 (4), 539-42

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