One Compartment Oral
Chapter 8 Problem 1
Plot of Cp versus Time after Oral Administration
One Compartment Model
Consider a drug with the parameter values in healthy subjects: F = 0.1; V = 766 L; kel = 0.105 hr-1; ka = 3.0 hr-1; CL = 74 L/hr.
Plot a concentration versus time curve after an oral dose of 192 mg.
Contrast this with the results obtained with the same dose given to a patient with severe cirrhosis.
Use the parameter values: F = 1.0; V = 777 L; kel = 0.080 hr-1; ka = 3.0 hr-1; CL = 62 L/hr.
Pentikainen et al., 1978
Add a second line with these parameter values using the Plot Line button.
| |
Healthy Subject |
Severe Cirrhosis |
| F |
0.1 |
1.0 |
| ka (hr-1) |
3.0 |
3.0 |
| kel (hr-1) |
0.105 |
0.080 |
| CL (L/hr) |
80.4 |
62.2 |
| V (L) |
766 |
777 |
References
- Adapted from Pentikainen, P.J., Neuvonen, P.J., Torpila, S. and Syvalahti, E. 1978 Effect of Cirrhosis of the Liver on the Pharmacokinetics of Chlormethiazole, Br. Med. J., 2, 861-3.
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