One Compartment Oral
Chapter 8 Problem 2
Plot of Cp versus Time after Oral Administration
One Compartment Model
Consider a drug with the parameter values in healthy subjects: F = 0.30; V = 290 L; kel = 0.173 hr-1; ka = 3.0 hr-1; CL = 860 ml/min.
Plot a concentration versus time curve after an oral dose of 80 mg.
Contrast this with the results obtained with the same dose given to a patient with severe cirrhosis. Use the parameter values: F = 0.42; V = 380 L; kel = 0.063 hr-1; ka = 3.0 hr-1; CL = 580 ml/min. Wood et al., 1978.
Add a second line with these parameter values using the Plot Line button.
| |
Healthy Subject |
Severe Cirrhosis |
| F |
0.3 |
0.42 |
| ka (hr-1) |
3.0 |
3.0 |
| kel (hr-1) |
0.173 |
0.063 |
| CL (L/hr) |
50.2 |
23.9 |
| V (L) |
290 |
380 |
References
- Wood, A.J.J., Kornhauser, D.M., Wilkinson, G.R., Shand, D.G. and Branch, R.A. 1978 The influence of cirrhosis on steady-state blood concentrations of unbound propranolol after oral administration, Clin. Pharmacokin., 3, 478-487 through Benet, L.Z., Massoud, N., and Gambertoglio, J.G. 1984. Pharmacokinetic Basis for Drug Treatment, Raven Press
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