One Compartment IV and Oral
Chapter 8 Problem 4
Plot of Cp versus Time
A drug was administered as an IV injection, and oral solution and two tablet formulations (one rapid and the other a slow release tablet). A dissolution step was included to model the two tablet formulations. Parameters values included kel = 0.077 hr-1,V = 81.3 L, ka = 0.113 hr-1. The two tablet formulations required kd = 0.405 hr-1 or 0.0261 hr-1. The dose were 25000 mg (Dose1 IV bolus), 20300 mg (Dose2 Oral solution), 19000 mg (Dose3 Oral rapid release tablet) and 21600 mg (Dose3 Oral slow release tablet). Simulate the concentration versus time curves after each dose.
Bevill et al., 1977.
Add additional lines using the Plot Line button.
Figure 8.4.1 One Compartment Model with Dissolution and Absorption
The equations for this model after IV Bolus, Solution, and Tablet doses were developed using Laplace transforms.
| |
IV Bolus |
Oral Solution |
Oral Tablet (fast) |
Oral Tablet (slow) |
| Dose1 |
25000 |
|
|
|
| Dose2 |
|
20300 |
|
|
| Dose13 |
|
|
19000 |
21600 |
| kel (hr-1) |
0.077 |
0.077 |
0.077 |
0.077 |
| V (L) |
81.3 |
81.3 |
81.3 |
81.3 |
| ka (hr-1) |
|
0.113 |
0.113 |
0.113 |
| kd (hr-1) |
|
|
0.405 |
0.0261 |
References
- Bevill, R.F., Dittert, L.W. and Bourne, D.W.A. 1977 Disposition of Sulfonamides in Food-Producing Animals IV: Pharmacokinetics of Sulfamethazine in Cattle following Administration of an Intravenous Dose and Three Oral Dosage Forms, J. Pharm. Sci., 66, 619-23
This page (http://www.boomer.org/c/p4/) was last modified: Monday, 30th Oct 2017 at 7:45 pm
Privacy Statement - 25 May 2018
iBook and pdf versions of this material and other PK material is available
Copyright © 2001-2022 David W. A. Bourne (david@boomer.org)