** FINAL OUTPUT FROM Boomer (v3.4.3) **      26 July 2018 --- 12:17:14 pm

 Title:  Simulation of PBPK Model
 Input: From pbpk_s.BAT                                                      
 Output:  To pbpk_S.OUT                                                      
 Data for [Vein] came from keyboard (or ?.BAT)
 Data for [Lung] came from keyboard (or ?.BAT)
 Data for [Artery] came from keyboard (or ?.BAT)
 Data for [Spleen] came from keyboard (or ?.BAT)
 Data for [Liver] came from keyboard (or ?.BAT)
 Data for [Kideny] came from keyboard (or ?.BAT)
 Data for [Heart] came from keyboard (or ?.BAT)
 Data for [Muscle] came from keyboard (or ?.BAT)
 Data for [Other] came from keyboard (or ?.BAT)
 Fitting algorithm: Simulation                 
 Numerical integration method: 4) Gears method with PEDERV                        
          with  9 de(s)
 With absolute error   0.1000E-02

 This simulation took      0.000     seconds

 Model and Parameter Definition

  #  Name                    Value       Type From To     Dep  Start Stop

  1) Dose                =   100.0        1    0    1       0    0    0
  2) Q Vein > Lung       =   2700.       15    1    3       0    0    0
  3) V Vein > Lung       =   800.0       16    1    1       0    0    0
  4) R Vein > Lung       =   1.000       17    0    0       0    0    0
  5) Q Lung > Artery     =   2700.       15    3    2       0    0    0
  6) V Lung > Artery     =   375.0       16    3    2       0    0    0
  7) R Lung > Artery     =  0.9000       17    0    0       0    0    0
  8) Q Artery > Liver    =   385.0       15    2    4       0    0    0
  9) V Artery > Liver    =   1600.       16    2    3       0    0    0
 10) R Artery > Liver    =   1.000       17    0    0       0    0    0
 11) Q Artery > Spleen   =   75.00       15    2    5       0    0    0
 12) V Artery > Spleen   =   1600.       16    2    0   10900    0    0
 13) R Artery > Spleen   =   1.000       17    0    0   11000    0    0
 14) Q Spleen > Liver    =   75.00       15    5    4       0    0    0
 15) V Spleen > Liver    =   60.00       16    5    4       0    0    0
 16) R Spleen > Liver    =  0.9000       17    0    0       0    0    0
 17) Q Artery > Kidney   =   330.0       15    2    6       0    0    0
 18) V Artery > Kidney   =   1600.       16    2    0   10900    0    0
 19) R Artery > Kidney   =   1.000       17    0    0   11000    0    0
 20) Q Artery > Heart    =   97.00       15    2    7       0    0    0
 21) V Artery > Heart    =   1600.       16    2    0   10900    0    0
 22) R Artery > Heart    =   1.000       17    0    0   11000    0    0
 23) Q Artery > Muscle   =   280.0       15    2    8       0    0    0
 24) V Artery > Muscle   =   1600.       16    2    0   10900    0    0
 25) R Artery > Muscle   =   1.000       17    0    0   11000    0    0
 26) Q Artery > Other    =   1458.       15    2    9       0    0    0
 27) V Artery > Other    =   1600.       16    2    0   10900    0    0
 28) R Artery > Other    =   1.000       17    0    0   11000    0    0
 29) Q Liver > Vein      =   460.0       15    4    1       0    0    0
 30) V Liver > Vein      =   790.0       16    4    5       0    0    0
 31) R Liver > Vein      =  0.9000       17    0    0       0    0    0
 32) Q Kidney > Vein     =   330.0       15    6    1       0    0    0
 33) V Kidney > Vein     =   165.0       16    6    6       0    0    0
 34) R Kidney > Vein     =  0.9000       17    0    0       0    0    0
 35) Q Heart > Vein      =   97.00       15    7    1       0    0    0
 36) V Heart > Vein      =   200.0       16    7    7       0    0    0
 37) R Heart > Vein      =  0.9000       17    0    0       0    0    0
 38) Q Muscle > Vein     =   280.0       15    8    1       0    0    0
 39) V Muscle > Vein     =  0.1830E+05   16    8    8       0    0    0
 40) R Muscle > Vein     =  0.9000       17    0    0       0    0    0
 41) Q Other > Vein      =   1458.       15    9    1       0    0    0
 42) V Other > Vein      =  0.1171E+05   16    9    9       0    0    0
 43) R Other > Vein      =   1.000       17    0    0       0    0    0
 44) Elimination         =   1.500        2    1    0       0    0    0

 Flow balance for Physiological Model

 Component  1) in    2625.     out    2700.    
 Component  2) in    2700.     out    2625.    
 Component  3) in    2700.     out    2700.    
 Component  4) in    460.0     out    460.0    
 Component  5) in    75.00     out    75.00    
 Component  6) in    330.0     out    330.0    
 Component  7) in    97.00     out    97.00    
 Component  8) in    280.0     out    280.0    
 Component  9) in    1458.     out    1458.    


 Data for [Vein] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000      0.125000       0.00000      -0.00000    
     2    1.000       0.00000      0.373818E-02   0.00000      -0.00000    
     3    2.000       0.00000      0.321745E-02   0.00000      -0.00000    
     4    3.000       0.00000      0.265861E-02   0.00000      -0.00000    
     5    4.000       0.00000      0.226096E-02   0.00000      -0.00000    
     6    5.000       0.00000      0.198956E-02   0.00000      -0.00000    
     7    6.000       0.00000      0.179307E-02   0.00000      -0.00000    
     8    8.000       0.00000      0.152539E-02   0.00000      -0.00000    
     9    12.00       0.00000      0.120288E-02   0.00000      -0.00000    
    10    14.00       0.00000      0.108590E-02   0.00000      -0.00000    
    11    16.00       0.00000      0.984646E-03   0.00000      -0.00000    
    12    18.00       0.00000      0.895320E-03   0.00000      -0.00000    
    13    21.00       0.00000      0.779349E-03   0.00000      -0.00000    
    14    24.00       0.00000      0.681208E-03   0.00000      -0.00000    

 Data for [Lung] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    1.000       0.00000      0.426212E-02   0.00000      -0.00000    
     3    2.000       0.00000      0.295246E-02   0.00000      -0.00000    
     4    3.000       0.00000      0.244706E-02   0.00000      -0.00000    
     5    4.000       0.00000      0.207250E-02   0.00000      -0.00000    
     6    5.000       0.00000      0.181775E-02   0.00000      -0.00000    
     7    6.000       0.00000      0.163385E-02   0.00000      -0.00000    
     8    8.000       0.00000      0.138517E-02   0.00000      -0.00000    
     9    12.00       0.00000      0.108981E-02   0.00000      -0.00000    
    10    14.00       0.00000      0.983457E-03   0.00000      -0.00000    
    11    16.00       0.00000      0.891557E-03   0.00000      -0.00000    
    12    18.00       0.00000      0.810554E-03   0.00000      -0.00000    
    13    21.00       0.00000      0.705434E-03   0.00000      -0.00000    
    14    24.00       0.00000      0.616496E-03   0.00000      -0.00000    

 Data for [Artery] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    1.000       0.00000      0.156298E-01   0.00000      -0.00000    
     3    2.000       0.00000      0.592682E-02   0.00000      -0.00000    
     4    3.000       0.00000      0.357489E-02   0.00000      -0.00000    
     5    4.000       0.00000      0.272008E-02   0.00000      -0.00000    
     6    5.000       0.00000      0.228149E-02   0.00000      -0.00000    
     7    6.000       0.00000      0.200557E-02   0.00000      -0.00000    
     8    8.000       0.00000      0.166274E-02   0.00000      -0.00000    
     9    12.00       0.00000      0.128840E-02   0.00000      -0.00000    
    10    14.00       0.00000      0.115988E-02   0.00000      -0.00000    
    11    16.00       0.00000      0.105012E-02   0.00000      -0.00000    
    12    18.00       0.00000      0.953901E-03   0.00000      -0.00000    
    13    21.00       0.00000      0.829404E-03   0.00000      -0.00000    
    14    24.00       0.00000      0.724216E-03   0.00000      -0.00000    

 Data for [Spleen] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    1.000       0.00000      0.123707E-01   0.00000      -0.00000    
     3    2.000       0.00000      0.889820E-02   0.00000      -0.00000    
     4    3.000       0.00000      0.510345E-02   0.00000      -0.00000    
     5    4.000       0.00000      0.329801E-02   0.00000      -0.00000    
     6    5.000       0.00000      0.246630E-02   0.00000      -0.00000    
     7    6.000       0.00000      0.203656E-02   0.00000      -0.00000    
     8    8.000       0.00000      0.160358E-02   0.00000      -0.00000    
     9    12.00       0.00000      0.120950E-02   0.00000      -0.00000    
    10    14.00       0.00000      0.108461E-02   0.00000      -0.00000    
    11    16.00       0.00000      0.980018E-03   0.00000      -0.00000    
    12    18.00       0.00000      0.889156E-03   0.00000      -0.00000    
    13    21.00       0.00000      0.772168E-03   0.00000      -0.00000    
    14    24.00       0.00000      0.673541E-03   0.00000      -0.00000    

 Data for [Liver] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    1.000       0.00000      0.695936E-02   0.00000      -0.00000    
     3    2.000       0.00000      0.777126E-02   0.00000      -0.00000    
     4    3.000       0.00000      0.615991E-02   0.00000      -0.00000    
     5    4.000       0.00000      0.462820E-02   0.00000      -0.00000    
     6    5.000       0.00000      0.352214E-02   0.00000      -0.00000    
     7    6.000       0.00000      0.277654E-02   0.00000      -0.00000    
     8    8.000       0.00000      0.194305E-02   0.00000      -0.00000    
     9    12.00       0.00000      0.130890E-02   0.00000      -0.00000    
    10    14.00       0.00000      0.115357E-02   0.00000      -0.00000    
    11    16.00       0.00000      0.103408E-02   0.00000      -0.00000    
    12    18.00       0.00000      0.934570E-03   0.00000      -0.00000    
    13    21.00       0.00000      0.809315E-03   0.00000      -0.00000    
    14    24.00       0.00000      0.704712E-03   0.00000      -0.00000    

 Data for [Kideny] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    1.000       0.00000      0.149482E-01   0.00000      -0.00000    
     3    2.000       0.00000      0.811522E-02   0.00000      -0.00000    
     4    3.000       0.00000      0.420484E-02   0.00000      -0.00000    
     5    4.000       0.00000      0.282330E-02   0.00000      -0.00000    
     6    5.000       0.00000      0.223871E-02   0.00000      -0.00000    
     7    6.000       0.00000      0.191842E-02   0.00000      -0.00000    
     8    8.000       0.00000      0.155613E-02   0.00000      -0.00000    
     9    12.00       0.00000      0.118958E-02   0.00000      -0.00000    
    10    14.00       0.00000      0.106867E-02   0.00000      -0.00000    
    11    16.00       0.00000      0.966484E-03   0.00000      -0.00000    
    12    18.00       0.00000      0.877331E-03   0.00000      -0.00000    
    13    21.00       0.00000      0.762275E-03   0.00000      -0.00000    
    14    24.00       0.00000      0.665179E-03   0.00000      -0.00000    

 Data for [Heart] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    1.000       0.00000      0.664045E-02   0.00000      -0.00000    
     3    2.000       0.00000      0.732794E-02   0.00000      -0.00000    
     4    3.000       0.00000      0.593159E-02   0.00000      -0.00000    
     5    4.000       0.00000      0.460534E-02   0.00000      -0.00000    
     6    5.000       0.00000      0.360989E-02   0.00000      -0.00000    
     7    6.000       0.00000      0.290182E-02   0.00000      -0.00000    
     8    8.000       0.00000      0.204954E-02   0.00000      -0.00000    
     9    12.00       0.00000      0.134812E-02   0.00000      -0.00000    
    10    14.00       0.00000      0.117763E-02   0.00000      -0.00000    
    11    16.00       0.00000      0.105025E-02   0.00000      -0.00000    
    12    18.00       0.00000      0.946612E-03   0.00000      -0.00000    
    13    21.00       0.00000      0.818222E-03   0.00000      -0.00000    
    14    24.00       0.00000      0.711900E-03   0.00000      -0.00000    

 Data for [Muscle] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    1.000       0.00000      0.260873E-03   0.00000      -0.00000    
     3    2.000       0.00000      0.402336E-03   0.00000      -0.00000    
     4    3.000       0.00000      0.464061E-03   0.00000      -0.00000    
     5    4.000       0.00000      0.503111E-03   0.00000      -0.00000    
     6    5.000       0.00000      0.532267E-03   0.00000      -0.00000    
     7    6.000       0.00000      0.555675E-03   0.00000      -0.00000    
     8    8.000       0.00000      0.591778E-03   0.00000      -0.00000    
     9    12.00       0.00000      0.638920E-03   0.00000      -0.00000    
    10    14.00       0.00000      0.654326E-03   0.00000      -0.00000    
    11    16.00       0.00000      0.665651E-03   0.00000      -0.00000    
    12    18.00       0.00000      0.673509E-03   0.00000      -0.00000    
    13    21.00       0.00000      0.679820E-03   0.00000      -0.00000    
    14    24.00       0.00000      0.680696E-03   0.00000      -0.00000    

 Data for [Other] :-

 DATA #   Time       Observed      Calculated    (Weight)  Weighted residual

     1    0.000       0.00000       0.00000       0.00000       0.00000    
     2    1.000       0.00000      0.202651E-02   0.00000      -0.00000    
     3    2.000       0.00000      0.290496E-02   0.00000      -0.00000    
     4    3.000       0.00000      0.309113E-02   0.00000      -0.00000    
     5    4.000       0.00000      0.309007E-02   0.00000      -0.00000    
     6    5.000       0.00000      0.301828E-02   0.00000      -0.00000    
     7    6.000       0.00000      0.291452E-02   0.00000      -0.00000    
     8    8.000       0.00000      0.267133E-02   0.00000      -0.00000    
     9    12.00       0.00000      0.218879E-02   0.00000      -0.00000    
    10    14.00       0.00000      0.197517E-02   0.00000      -0.00000    
    11    16.00       0.00000      0.178258E-02   0.00000      -0.00000    
    12    18.00       0.00000      0.160987E-02   0.00000      -0.00000    
    13    21.00       0.00000      0.138425E-02   0.00000      -0.00000    
    14    24.00       0.00000      0.119345E-02   0.00000      -0.00000    

 Calculation of AUC and AUMC based on trapezoidal rule

 AUC and AUMC for [Vein]          using Calculated data

       Time         Concentration      AUC             AUMC

      0.00000         0.125000    
      1.00000         0.373818E-02    0.643691E-01    0.186909E-02
      2.00000         0.321745E-02    0.678469E-01    0.695563E-02
      3.00000         0.265861E-02    0.707849E-01    0.141610E-01
      4.00000         0.226096E-02    0.732447E-01    0.226708E-01
      5.00000         0.198956E-02    0.753700E-01    0.321666E-01
      6.00000         0.179307E-02    0.772613E-01    0.425198E-01
      8.00000         0.152539E-02    0.805798E-01    0.654813E-01
      12.0000         0.120288E-02    0.860363E-01    0.118757    
      14.0000         0.108590E-02    0.883251E-01    0.148394    
      16.0000         0.984646E-03    0.903957E-01    0.179351    
      18.0000         0.895320E-03    0.922756E-01    0.211221    
      21.0000         0.779349E-03    0.947876E-01    0.259944    
      24.0000         0.681208E-03    0.969785E-01    0.309017    
                                      0.112162         1.01187    
 AUC and AUMC extrapolated
      from the last data point          13.5 %          69.5 %

 Terminal half-life       15.4     (    -0.449E-01)

 Secondary Parameters

 MRT =      9.0215    

 Half-life values for each first order rate constant

   Parameter  44 has a half-life of Elimination is      0.462    

 Dose/AUC (= Clearance/F)

   Parameter   1 gives Dose/AUC (CL/F) of       892.    

 Calculation of AUC and AUMC using Method 9 of R.D. Purves

 AUC and AUMC for [Vein]          using Calculated data

       Time         Concentration      AUC             AUMC

      0.00000         0.125000    
      1.00000         0.373818E-02    0.345503E-01    0.877910E-02
      2.00000         0.321745E-02    0.380216E-01    0.139427E-01
      3.00000         0.265861E-02    0.409508E-01    0.212190E-01
      4.00000         0.226096E-02    0.434052E-01    0.297763E-01
      5.00000         0.198956E-02    0.455276E-01    0.393044E-01
      6.00000         0.179307E-02    0.474172E-01    0.496809E-01
      8.00000         0.152539E-02    0.507284E-01    0.727705E-01
      12.0000         0.120288E-02    0.561595E-01    0.126651    
      14.0000         0.108590E-02    0.584463E-01    0.156341    
      16.0000         0.984646E-03    0.605152E-01    0.187340    
      18.0000         0.895320E-03    0.623937E-01    0.219246    
      21.0000         0.779349E-03    0.649017E-01    0.268065    
      24.0000         0.681208E-03    0.670892E-01    0.317211    
                                      0.822731E-01     1.02006    
 AUC and AUMC extrapolated
      from the last data point          18.5 %          68.9 %

 Terminal half-life       15.4     (    -0.449E-01)

 Secondary Parameters

 MRT =      12.399    

 Half-life values for each first order rate constant

   Parameter  44 has a half-life of Elimination is      0.462    

 Dose/AUC (= Clearance/F)

   Parameter   1 gives Dose/AUC (CL/F) of      0.122E+04


 Calculation of AUC and AUMC based on trapezoidal rule

 AUC and AUMC for [Liver]         using Calculated data

       Time         Concentration      AUC             AUMC

      0.00000          0.00000    
      1.00000         0.695936E-02    0.347968E-02    0.347968E-02
      2.00000         0.777126E-02    0.108450E-01    0.147306E-01
      3.00000         0.615991E-02    0.178106E-01    0.317417E-01
      4.00000         0.462820E-02    0.232046E-01    0.502380E-01
      5.00000         0.352214E-02    0.272798E-01    0.682997E-01
      6.00000         0.277654E-02    0.304291E-01    0.854347E-01
      8.00000         0.194305E-02    0.351487E-01    0.117638    
      12.0000         0.130890E-02    0.416526E-01    0.180141    
      14.0000         0.115357E-02    0.441151E-01    0.211997    
      16.0000         0.103408E-02    0.463027E-01    0.244693    
      18.0000         0.934570E-03    0.482714E-01    0.278060    
      21.0000         0.809315E-03    0.508872E-01    0.328787    
      24.0000         0.704712E-03    0.531582E-01    0.379650    
                                      0.684339E-01     1.07739    
 AUC and AUMC extrapolated
      from the last data point          22.3 %          64.8 %

 Terminal half-life       15.0     (    -0.461E-01)

 Secondary Parameters

 MRT =      15.743    

 Half-life values for each first order rate constant

   Parameter  44 has a half-life of Elimination is      0.462    

 Dose/AUC (= Clearance/F)

   Parameter   1 gives Dose/AUC (CL/F) of      0.146E+04

 Calculation of AUC and AUMC using Method 9 of R.D. Purves

 AUC and AUMC for [Liver]         using Calculated data

       Time         Concentration      AUC             AUMC

      0.00000          0.00000    
      1.00000         0.695936E-02    0.347968E-02    0.347968E-02
      2.00000         0.777126E-02    0.108375E-01    0.145841E-01
      3.00000         0.615991E-02    0.177719E-01    0.317859E-01
      4.00000         0.462820E-02    0.231295E-01    0.504101E-01
      5.00000         0.352214E-02    0.271796E-01    0.685432E-01
      6.00000         0.277654E-02    0.303141E-01    0.857213E-01
      8.00000         0.194305E-02    0.349843E-01    0.118135    
      12.0000         0.130890E-02    0.414049E-01    0.181497    
      14.0000         0.115357E-02    0.438641E-01    0.213415    
      16.0000         0.103408E-02    0.460495E-01    0.246157    
      18.0000         0.934570E-03    0.480165E-01    0.279563    
      21.0000         0.809315E-03    0.506278E-01    0.330390    
      24.0000         0.704712E-03    0.528952E-01    0.381328    
                                      0.681709E-01     1.07907    
 AUC and AUMC extrapolated
      from the last data point          22.4 %          64.7 %

 Terminal half-life       15.0     (    -0.461E-01)

 Secondary Parameters

 MRT =      15.829    

 Half-life values for each first order rate constant

   Parameter  44 has a half-life of Elimination is      0.462    

 Dose/AUC (= Clearance/F)

   Parameter   1 gives Dose/AUC (CL/F) of      0.147E+04

      Plots of observed (*) and calculated values (+)
           versus time for [Vein]                                                          . Superimposed points (X)

   0.1250      Linear                     0.1250      Semi-log
 |+                                      |                                     
 |                                       |+                                    
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       | +                                   
 |                                       |   +                                 
 |                                       |    +                                
 |                                       |      ++                             
 |                                       |         +                           
 |                                       |            +                        
 |                                       |                  +                  
 |                                       |                     +  +            
 |                                       |                           +         
 |*X XX XX X  X     X  X  X  X   X    X  |                               +    +
 |_____________________________________  |**_**_**_*__*_____*__*__*__*___*____*
    0.000                                 0.6812E-03
 0              <-->             24.     0              <-->             24.    
      Plots of observed (*) and calculated values (+)
           versus time for [Lung]                                                          . Superimposed points (X)

   0.4262E-02  Linear                     0.4262E-02  Semi-log
 | +                                     | +                                   
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |   +                                 
 |                                       |                                     
 |                                       |                                     
 |                                       |    +                                
 |   +                                   |                                     
 |                                       |                                     
 |                                       |      +                              
 |    +                                  |                                     
 |                                       |       +                             
 |                                       |         +                           
 |      +                                |                                     
 |                                       |                                     
 |       +                               |            +                        
 |         +                             |                                     
 |                                       |                                     
 |            +                          |                                     
 |                                       |                  +                  
 |                  +                    |                     +               
 |                     +  +              |                                     
 |                           +           |                        +            
 |                               +    +  |                           +         
 |                                       |                                     
 |                                       |                               +     
 |                                       |                                     
 |X* ** ** *  *     *  *  *  *   *    *  |                                    +
 |_____________________________________  |X*_**_**_*__*_____*__*__*__*___*____*
    0.000                                 0.6165E-03
 0              <-->             24.     0              <-->             24.    
      Plots of observed (*) and calculated values (+)
           versus time for [Artery]                                                        . Superimposed points (X)

   0.1563E-01  Linear                     0.1563E-01  Semi-log
 | +                                     |                                     
 |                                       | +                                   
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |   +                                 
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |    +                                
 |                                       |                                     
 |                                       |                                     
 |                                       |      +                              
 |   +                                   |       +                             
 |                                       |                                     
 |                                       |         +                           
 |                                       |            +                        
 |                                       |                                     
 |    +                                  |                                     
 |      +                                |                  +                  
 |       +                               |                     +               
 |         +  +                          |                        +            
 |                  +  +  +              |                           +         
 |                           +   +    +  |                               +     
 |X* ** ** *  *     *  *  *  *   *    *  |                                    +
 |_____________________________________  |X*_**_**_*__*_____*__*__*__*___*____*
    0.000                                 0.7242E-03
 0              <-->             24.     0              <-->             24.    
      Plots of observed (*) and calculated values (+)
           versus time for [Spleen]                                                        . Superimposed points (X)

   0.1237E-01  Linear                     0.1237E-01  Semi-log
 | +                                     | +                                   
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |   +                                 
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |   +                                   |                                     
 |                                       |    +                                
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |      +                              
 |                                       |                                     
 |                                       |                                     
 |                                       |       +                             
 |    +                                  |                                     
 |                                       |         +                           
 |                                       |                                     
 |                                       |                                     
 |                                       |            +                        
 |      +                                |                                     
 |                                       |                  +                  
 |       +                               |                                     
 |         +                             |                     +               
 |            +                          |                        +            
 |                  +  +  +  +           |                           +         
 |                               +    +  |                               +     
 |X* ** ** *  *     *  *  *  *   *    *  |                                    +
 |_____________________________________  |X*_**_**_*__*_____*__*__*__*___*____*
    0.000                                 0.6735E-03
 0              <-->             24.     0              <-->             24.    
      Plots of observed (*) and calculated values (+)
           versus time for [Liver]                                                         . Superimposed points (X)

   0.7771E-02  Linear                     0.7771E-02  Semi-log
 |   +                                   |   +                                 
 |                                       |                                     
 |                                       | +                                   
 |                                       |    +                                
 | +                                     |                                     
 |                                       |                                     
 |                                       |                                     
 |    +                                  |      +                              
 |                                       |                                     
 |                                       |                                     
 |                                       |       +                             
 |                                       |                                     
 |                                       |                                     
 |      +                                |         +                           
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |       +                               |                                     
 |                                       |            +                        
 |                                       |                                     
 |         +                             |                                     
 |                                       |                                     
 |                                       |                                     
 |            +                          |                  +                  
 |                                       |                     +               
 |                  +                    |                                     
 |                     +                 |                        +            
 |                        +  +   +       |                           +         
 |                                    +  |                                     
 |                                       |                               +     
 |X* ** ** *  *     *  *  *  *   *    *  |                                    +
 |_____________________________________  |X*_**_**_*__*_____*__*__*__*___*____*
    0.000                                 0.7047E-03
 0              <-->             24.     0              <-->             24.    
      Plots of observed (*) and calculated values (+)
           versus time for [Kideny]                                                        . Superimposed points (X)

   0.1495E-01  Linear                     0.1495E-01  Semi-log
 | +                                     | +                                   
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |   +                                 
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |    +                                
 |   +                                   |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |      +                              
 |                                       |                                     
 |                                       |       +                             
 |                                       |         +                           
 |                                       |                                     
 |    +                                  |            +                        
 |                                       |                                     
 |                                       |                                     
 |      +                                |                  +                  
 |       +                               |                     +               
 |         +  +                          |                        +            
 |                  +  +                 |                           +         
 |                        +  +   +    +  |                               +     
 |X* ** ** *  *     *  *  *  *   *    *  |                                    +
 |_____________________________________  |X*_**_**_*__*_____*__*__*__*___*____*
    0.000                                 0.6652E-03
 0              <-->             24.     0              <-->             24.    
      Plots of observed (*) and calculated values (+)
           versus time for [Heart]                                                         . Superimposed points (X)

   0.7328E-02  Linear                     0.7328E-02  Semi-log
 |   +                                   |                                     
 |                                       |   +                                 
 |                                       | +                                   
 | +                                     |    +                                
 |                                       |                                     
 |                                       |                                     
 |    +                                  |      +                              
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |       +                             
 |                                       |                                     
 |      +                                |         +                           
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |       +                               |                                     
 |                                       |            +                        
 |                                       |                                     
 |         +                             |                                     
 |                                       |                                     
 |                                       |                                     
 |            +                          |                  +                  
 |                                       |                                     
 |                                       |                     +               
 |                  +                    |                        +            
 |                     +  +              |                                     
 |                           +   +       |                           +         
 |                                    +  |                                     
 |                                       |                               +     
 |X* ** ** *  *     *  *  *  *   *    *  |                                    +
 |_____________________________________  |X*_**_**_*__*_____*__*__*__*___*____*
    0.000                                 0.7119E-03
 0              <-->             24.     0              <-->             24.    
      Plots of observed (*) and calculated values (+)
           versus time for [Muscle]                                                        . Superimposed points (X)

   0.6807E-03  Linear                     0.6807E-03  Semi-log
 |                                    +  |                                    +
 |                        +  +   +       |                  +  +  +  +   +     
 |                  +  +                 |            +                        
 |                                       |         +                           
 |            +                          |      ++                             
 |                                       |    +                                
 |         +                             |                                     
 |       +                               |   +                                 
 |      +                                |                                     
 |                                       |                                     
 |    +                                  |                                     
 |                                       |                                     
 |                                       |                                     
 |   +                                   | +                                   
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 | +                                     |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |X* ** ** *  *     *  *  *  *   *    *  |                                     
 |_____________________________________  |X*_**_**_*__*_____*__*__*__*___*____*
    0.000                                 0.6807E-04
 0              <-->             24.     0              <-->             24.    
      Plots of observed (*) and calculated values (+)
           versus time for [Other]                                                         . Superimposed points (X)

   0.3091E-02  Linear                     0.3091E-02  Semi-log
 |    +                                  |    +                                
 |      ++                               |      ++                             
 |   +     +                             |   +     +                           
 |                                       |                                     
 |                                       |                                     
 |            +                          |            +                        
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                  +                    |                                     
 |                                       |                                     
 | +                   +                 |                  +                  
 |                                       |                                     
 |                        +              |                                     
 |                                       | +                                   
 |                           +           |                     +               
 |                                       |                                     
 |                               +       |                                     
 |                                       |                        +            
 |                                    +  |                                     
 |                                       |                                     
 |                                       |                           +         
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |                                       |                               +     
 |                                       |                                     
 |                                       |                                     
 |                                       |                                     
 |X* ** ** *  *     *  *  *  *   *    *  |                                    +
 |_____________________________________  |X*_**_**_*__*_____*__*__*__*___*____*
    0.000                                 0.1193E-02
 0              <-->             24.     0              <-->             24.