Chapter 14
Multiple IV Bolus Dose Administration
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Multiple IV Bolus Dose Administration
Student Objectives for this Chapter
After completing the material in this chapter each student should:-
- understand and be able to describe drug accumulation after repeated dose administration
- be able to use the integrated equations for drug concentration after multiple IV bolus doses
- be able to calculate suitable dosing regimens including loading dose, maintenance dose, and dosing interval
- be able to define, use, and calculate the parameters:
- dosing interval, τ
- fraction remaining at the end of the dosing interval, R (= e-kel*Τ)
- accumulation factor, 1/(1-R)
- maximum plasma concentration, Cpmax
- minimum plasma concentration, Cpmin
- infusion duration, D
- be able to calculate suitable multiple dose regimen to achieve desired Cpmin and Cpmax values
This Chapter will consider drug pharmacokinetics after multiple IV bolus dose administration. But, first a review of the equations for a single dose administration.
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